Regulatory B Cells: Key Players in Hepatocellular Carcinoma Progression

Both Cells mediated and humoral immunity is considered as key players in the immunopathology of HCC. Cancer cells are recognized and eliminated by the innate immune system such as nature killer cells (NK) and macrophages then by the adaptive immune response mainly by Cytotoxic T lymphocytes CTL before they became clinically apparent. The tumor cells can escape from the immune system by decreasing the expression of tumor-specific antigens and even lose the major MHCI and MHC-II antigens and so the tumor cells became less immunogenic, escaped from immune attack, and suppressed antitumor immune response leading to tumor growth and genesis resulting from the immune evasion and escape [2].